Fat Burning Pills Part One: The Basics

Nutrition, Weight Loss Add comments

This one might get a little sciency…

I’ve railed about fat burning supplements before (see: Quicktrim Commercial Makes Me Sad Inside), and most of them are utter garbage.

But there are a few supplement combinations that can help accelerate fat loss, when combined with a tight diet and the right exercise.

fat loss pills

Now for the basics:

Fat cells have two types of andrenergic receptors (also called adrenoceptors).  Andrenergic receptors are activated by catecholamines (epinephrine, norepinephrin, and certain andrenergic drugs).

When these catecholamines bind to the fat cells’s receptors, the cell activates the sympathetic nervous system – your fight-or-flight response.  This mobilizes energy and redirects blood flow to the muscles.

The two andrenergic receptors we’re interested in are the A2 receptors and B1 receptors.

A2 receptors:

  • Inhibit insulin release in the pancreas
  • Release glucagon from the pancreas.
  • Contract the sphincters of the gastrointestinal tract
  • Lead to negative feedback in the neuronal synapses – presynaptic inhibition of noradrenalin release in CNS
  • Increase thrombocyte aggregation

B1 receptors:

  • Increase cardiac output by:
  1. increasing heart rate (positive chronotropic effect)
  2. conduction velocity (positive dromotropic effect)
  3. stroke volume (by enhancing contractility)
  • Increase renin secretion from juxtaglomerular cells of the kidney
  • Increase ghrelin secretion from the stomach
  • Activate lipase (fat cell breakdown enzyme)

But since fat cells have little bloodflow to them (one of the reasons they are hard to break down), norepinephrin is mostly what attaches to these receptors.

Epinephrin is only carried by major blood vessels, and fat only has minor blood vessels.  That’s why norepinephrin is what we’re looking at for fat cell breakdown.

For fat loss, the B1 receptors are our friends and the A2 receptors most definitely are not.

The A2s block fat breakdown enzymes, promote raised triglyceride levels, and block the norepinephrine at the nerve site which means B1 receptors aren’t activated.

And guess what? Low-calorie diets promote the formation of more A2 sites.  So when you starve yourself you’re actually making your stubborn fat even more stubborn.

A2s actually are located in those “stubborn fat” sites: the hips, butt, and thighs in women, and the belly in men.  (Your stubborn sites may be different, those are just the most common ones I see)

B1 receptors (the helpful ones) can be stimulated by activating your central nervous system and causing your body to release norepinephrine.  This is actually relatively simple.

Signs that you’ve activated your B1 receptors include:

  1. Elevated heart rate
  2. Elevated blood pressure
  3. Elevated body temperature

If you aren’t sweaty with a racing heart and tremors, you aren’t activating your B1 receptors enough to help with fat loss.

In order, the best stuff for activating your B1s:

  • Clenbuterol (works for 36-48 hrs)
  • Mabuterol (20 hrs)
  • Ephedrine (3-4 hours)
  • Albuterol (2-6 hrs)

Of course, all of these can be DANGEROUS.  Don’t screw around with them – especially if you have a heart condition.

Clenbuterol is used as a bronchodialator for asthma patients.  It’s not illegal but you can’t purchase it over the counter.  And it’s banned for athletic use (the stimulant effects increase athletic performance).

Mabuterol and albuterol are also banned substances, though not as strong.

Ephedrine is the best option for a fat burning pill: It is strong enough to work, but not so strong that sleep will never be an option.

Dosage information will be in the next post…

One Response to “Fat Burning Pills Part One: The Basics”

  1. Fat Burning Pills Part Two: Ephedra, Caffeine, And Aspirin | Wold Fitness Notebook Says:

    […] Fat Burning Pills Part One we covered the pathways that would make a supplement help you burn fat.  For the right balance of […]